|
KMID : 1149120190160010001
|
|
Journal of the Korean Society for Psoriasis
2019 Volume.16 No. 1 p.1 ~ p.7
|
|
|
Treatment strategies in patients with psoriasis during pregnancy
|
|
Kim Jung-Whan
Kim Gun-Wook
|
|
|
Abstract
|
|
|
|
Psoriasis is a chronic inflammatory skin disease and its treatment of psoriasis in pregnant and lactating women presents a special challenge. Psoriasis generally improves during pregnancy due to hormonal change which Th1 cells are downregulated while Th2 cells and Treg cells are up-regulated. In treating pregnant patients, the benefits of treatment and risks to the mother and the fetus must be considered. Along with emollients, topical corticosteroids are considered to be the first-line treatment in patients with psoriasis. For moderate-tosevere psoriasis, narrowband UVB phototherapy is preferred. Methotrexate and acitretin are absolutely contraindicated in pregnancy. Cyclosporine can be used but its use should be limited to the shortest duration at the lowest possible dose. Despite limited safety data, etanercept is a good alternative because it has less placental transfer infliximab and adalimumab. Ustekinumab and secukinumab were both classified in FDA pregnancy risk category B, but available data are limited. In this review, we provide an overview of the key considerations for managing psoriasis in pregnant women.
|
|
|
KEYWORD
|
|
|
Pregnancy, Psoriasis, Treatment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|